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Synthesis of Essential Drugs, by Ruben Vardanyan, Victor Hruby
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This book represents an effort to express a long overdue need of compiling information which has been accumulated over the course of more than 30 years of our work in the area of the synthesis of medicinal drugs. Our effort fills obvious gaps that exist in the literature of drug synthesis.
The synthesis of various groups of drugs are presented in an order similar to that traditionally presented in a pharmacology curriculum. This was done with a very specific goal in mind – to harmonize the chemical aspects with the pharmacology curriculum in a manner useful to chemists.
Practically every chapter begins with an accepted brief definition and description of a particular group of drugs, proposes their classification, and briefly explains the present model of their action. This is followed by a detailed description of methods for their synthesis.
Of the thousands of drugs existing on the pharmaceutical market, we mainly discuss generic drugs that are included in the WHO’s "Essential List of Drugs."
For practically all of the 700+ drugs described in the book, references (around 2350) to the methods of their synthesis are given along with the most widespread synonyms.
This book will provide the kind of information that will be of interest to those who work, or plan to begin work in the captivating areas of biologically active compounds and the synthesis of medicinal drugs.
* Provides a brief description of methods of synthesis, activity and implementation of all drug types
* Includes synonyms
* Includes over 2300 references
- Sales Rank: #3991152 in eBooks
- Published on: 2006-03-10
- Released on: 2006-03-10
- Format: Kindle eBook
Review
* Provides a brief description of methods of synthesis, activity and implementation of all drug types
* Includes synonyms
* Includes over 2300 references
About the Author
Research Professor, Department of Chemistry and Biochemistry, University of Arizona
Regents Professor Emeritus, Department of Chemistry and Biochemistry, University of Arizona
Most helpful customer reviews
15 of 15 people found the following review helpful.
False Advertising - useful book, but not at all what it claims
By Jeff Evarts
If you bought a $300-ish book titled "Synthesis of Essential Drugs", you'd expect to open it and find a book detailing the synthesis of essential drugs. This is not what you get with this book. The contents of this book are indeed useful, but if you're looking for details on drug synthesis, this is not it.
What it provides: A comprehensive list of WHO essential drugs, a good summary of each "group", the group's metabolic actions, and a good description of the molecular and pharmaceutical differences between them. It also details a single list of precursor substances for each drug, along with (unbalanced and incomplete) chemical equations related to that precursor chain.
What it does not provide: Methods, catalysts, agents, equipment, environment, and dangers of synthesis. So (virtually) no mention of catalysts, no mention of temperature of reaction, no mention of vessels, yields, correctness-checking, etc. THESE are the primary data associated with the synthesis of a drug, and they are essentially nowhere to be found in this book.
Perhaps a title would be "A sketch of a precursor chain for each one of WHO's essential drugs, with detailed notes on their metabolic actions"
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